Should we recommend precautions during a hantavirus endemic?

An atypical pneumonia in a renal transplant patient We report the case of a 27-year-old man who suffered from end-stage renal disease secondary to medullary cys-tic kidney disease and who received a kidney transplant in November 2007. The post-transplant immunosuppressive regimen consisted of methylprednisolone, tacrolimus and mycophenolate mofetil. One year later, the patient presented with a non-productive cough and pain at the right side of the chest. He did not have fever. Physical examination revealed breath sounds reduction and rales over the right lung. On blood examination, C-reactive protein (CRP) was elevated at 52.3 mg/L (normal range <5 mg/L), and white blood cell (WBC) count was 13 × 10 3 /mm 3 (normal range 3.6–9.6 × 10 3 /mm 3) with 9.2 × 10 3 /mm 3 neutrophils (normal range 1.4–6.7 × 10 3 /mm 3). Serum creatinine was 177 µmol/L (2.0 mg/dL) (normal range 0.5–1.5 mg/dL), and urea was 8.5 mmol/L (51 mg/dL) (normal range 15–40 mg/dL). Tacrolimus level was in the therapeutic range. Chest radiography showed the presence of an opacity at the right lung. Empirical treatment with intravenous amoxicillin clavulanate and clarithromycin was initiated. After a few days, the patient's symptoms resolved, and CRP and WBC count returned to normal. Antibiotic therapy was continued orally. However, the infiltrate remained radiologically unchanged. Two months later, our patient was readmitted with general malaise. Laboratory tests at that time showed CRP of 145.5 mg/L, urea of 70 mg/dL, creatinine of 2.5 mg/dL and WBC count of 6.9 × 10 3 /mm 3. Chest computed to-mography (CT) scan showed no reduction of the pulmonary infiltrate. Therapy with amoxicillin clavulanate was reinitiated. Two sputum cultures and one blood culture yielded growth of Gram-positive coccobacilli, later identified as Rhodococcus equi. After susceptibility testing, therapy was switched to oral doxycycline and ciprofloxa-cin [1], and the patient could be discharged. A week later, he was readmitted for an Escherichia coli sepsis of unknown origin. Based on advanced literature study [1,2], it was decided to treat the patient with oral ciprofloxacin (2 × 500 mg/day) and rifampicin (2 × 450 mg/day) for at least 6 months. A CT-guided biopsy of the lesion was performed 7 months after initial diagnosis and showed the presence of granulomatous inflammation without necrosis. Additional stains and tissue cultures remained negative, namely for mycobacteria. Currently, after 1 year of therapy, the patient's symptoms have completely resolved, and chest CT scan shows limited …